Introduction: Stem cell therapy provides new ideas for the new clinical solution of frostbite, stem cells effectively curb the progress of the disease, bring hope to patients!


Amyotrophic lateral sclerosis, commonly known as as gradual frostbite, is a destructive neurodegenerative disease characterized by the loss of upper and lower motor neurons, which can lead to progressive muscle weakness and atrophy, respiratory failure, the incidence rate of 1/100000 to 2/100000, the pathogenesis is not yet accurate.


The FDA approved liruquine (a neuroprotective drug that blocks excessive nerve transmission) and Ida laphen (antioxidant) for the treatment of frostbite, but were unable to contain the disease's development. Stem cell therapy is a hot research topic for neurodegenerative diseases, stem cells can be differentiated into the desired cell types, such as new neurons to replace degraded or dead neurons, to curb the sexual development of the disease. Stem cell therapy has been proven in both animal model trials and human clinical trials.

First, animal model testing


Numerous studies have shown that stem cell therapy can prolong the survival of mice with frostbite, detect nerve markers of transplanted cells in transplanted mice' brains and spinal cords, and find widely distributed stem cells in surrounding organs, which can be transplanted intravenously into model mice, and have been found to delay the onset of the disease and prolong survival in mice.


Studies have shown that stem cells from human or rodent origin were transplanted into standard SOD1G93A mice, where the movement activity and movement function of the limbs were better restored, weight loss slowed down, and the movement function and life span of mice were significantly improved.

Second, human clinical trials

(1) Safety: Early observation of patients with frostbite and phase 0 stem cell therapy trials showed that the in vitro in vitro injection of autoitherapy stem cells was well tolerated and no other adverse reactions occurred;


(2) Effectiveness: In recent years, more and more studies have conducted more detailed stem cell therapy trials on patients with frostbite. There have been numerous literatures reporting that the disease in patients with frostbite treated with stem cells has rarely worsened or progressed slowly compared to standard treatment-to-treatment controls, especially with significant improvements in pseudo-myeloid paralysis and respiratory symptoms.


Another researcher used cultured differentiated stem cells to enhance the secretion of neurotrophic factors, these cell intramuscular intrauterine injections to 14 patients, 6 months of follow-up period frostbite function scoring scale score and the degree of decline in hard lung capacity are reduced, stem cell therapy improved the clinical symptoms of patients with frostbite.

Ye et al. treated patients with frostbite with stem cells to assess their sleep quality and emotional effects, and found that the incidence of sleep disorders decreased in patients treated with stem cells, improved sleep quality, improved patients' negative dull mood, and showed that stem cell therapy could improve the quality of life of patients with frostbite.


Clinical Trial Progress: According to (National Institutes of Health Clinical Research Database official website), researchers have completed five clinical trials for stem cell treatment of frostbite, mainly in the clinical phase II, to further explore the effectiveness and safety of stem cell treatment of frostbite, and achieved good results.
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