With the gradual increase of the number of sick people in recent years, the treatment of osteoarthritis has become a concern of many patients.


 

Recently, a number of domestic media reports, another for knee osteoarthritis, the umbilical cord interstitia stem cell research and development (IND) application was accepted, once again demonstrated the clinical application of interstitia stem cells in the field of osteoarthritis prospects.

Currently, according to the State Drug Administration (NMPA), a total of three new interstation stem cell drugs for knee osteoarthritis have been approved clinically.


 

osteoarthritis

it seriously affects people's lives

Osteoarthritis (osteoarthritis, OA) is a common chronic disease that affects the weight-bearing membrane joints and causes joint pain and dysfunction.

Age, physical fitness and sports injury are the main causes of osteoarthritis.


 

With an aging population and an increase in the number of obese people and increased participation in sports, OA will become the fourth largest cause of physical activity in the world.

Arthritis is already a common disease in modern people, to knee arthritis, for example, adolescent cartilage thickness of 2.5 centimeters, with age, frequent use and gradually thinning, to 55 years old generally only 0.5 centimeters, if there are trauma or long-term weight-bearing, cartilage may be thinner, or even cracked, bone spurs.

According to the World Health Organization, China will become the world's largest number of OA disease countries.

Osteoarthritis seriously threatens human health and life, and brings a huge economic burden to society.

Traditional methods do not cure the problem

Among the traditional treatment methods, non-drug therapy and drug therapy are mainly.

At the onset of the disease, most patients will use anti-inflammatory analgesic drugs to reduce or control symptoms, but this method can not change the progression of lesions, only during the acute pain attack to play a role in the treatment;

In late cases, under conditions where the whole body can tolerate surgery, artificial joint replacement, joint nerve cutting or bone amputation may be performed as appropriate in order to improve joint function.

Traditional methods of intervention of osteoarthritis, such as functional exercise, physiotherapy, lifestyle changes and the use of painkillers, can only temporarily relieve symptoms without improving the pathogenesis of osteoarthritis or reversing the progression of osteoarthritis.


 

Joint replacement surgery is required for more severe cases, and the method has a service life, complex maintenance during use, and is not suitable for a large amount of activity in young patients.

Therefore, finding an effective method to intervene osteoarthritis has become one of the hot research topics in this field.

Stem cells offer new hope to osteoarthritis patients

In recent years, the international treatment of osteoarthritis stem cell new drugs have been approved for the market.

As early as 2009, Europe approved the launch of a stem cell drug called Chondrocelect for the treatment of knee cartilage defects;

In 2012, another interstitial stem cell drug, Cartism, was approved for the treatment of degenerative arthritis and knee cartilage injury;

In 2016, the stem cell drug Maci was approved in the United States to treat knee cartilage injury...

These clinical applications and developments mark the growing maturity of stem cell therapy in the field of osteoarthritis treatment.

The use of stem cells to treat osteoarthritis has become a new research direction.

Stem cell therapy effectively treats osteoarthritis through two mechanisms:

1. Stem cells repair damaged tissue directly through multi-directional differentiation potential.

Stem cells are converted into bone cells, cartilage cells, and bone joint cartilage repair under specific induction conditions inside and outside the body.

2. Stem cells by secreting a variety of factors, such as conversion growth factor -beta 1, insulin-like growth factor-1, etc. enough to induce the stem cells themselves to cartilage cell differentiation, inhibit the progress of local inflammation, promote local damaged tissue self-repair ability, so as to achieve the purpose of intervention.

Fundamentally improve the cartilage defects of arthritis patients, improve the efficacy of the patients while reducing the pain and side effects in the course of treatment.

Interstable stem cells can differentiate into bone and cartilage cells to fill cell defects.

An article published in the International Journal of Molecular Science suggests that cartilage regeneration occurs after injection of osteoarthritis stem cells.

The study carried out interstellar injection of interstellar charge stem cells in the joint cavity on the mouse model of osteoarthritis in the jaw, and the results showed a significant increase in cartilage thickness in animal model mice.


 

In recent years, it has been found that interstitial stem cells can increase cartilage deposition, mainly because of the nutritional role of mesoplasmic stem cells in stimulating cartilage cell proliferation and matrix deposition, in which immune regulation and side secretion effects play a greater role, rather than based on mesoplasmic stem cells directly differentiated into cartilage cells.

Interstitia stem cells to treat arthritis will not cause obvious side effects, systemic venous retransmission can effectively regulate patient immunity, interstitious stem cells can not only improve the clinical symptoms of arthritis, but also to achieve joint cartilage repair regeneration.

Stem cell therapy offers new hope for a cure for the vast majority of arthritis patients.

We look forward to higher levels of evidence and more ground-breaking cell therapy technologies to further advance this technology.

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